The second in command is expected to start his tour in the region today.
During the five-day tour in the region, Ruto is expected to launch several projects aimed at transforming the lives of the people.
The tour comes barely a week after President Uhuru Kenyatta pitched his tent in the region for five days.
Ruto, who is considered as one of the frontrunners in the race for Presidency in 2022, will make a stopover in Taita Taveta where he is set to unveil several projects including KoraKora canal water, coconut and nuts projects among others.
The DP, who will be accompanied by a number of his allies and government officials, will then proceed to Kilifi where he is expected to visit the National Irrigation Board project and the Baricho Water stabilisation supply.
The NIB Projects involves the promotion of coconut and cashew nut farming. The farmers are set to benefit from free seedlings when Ruto commissions the projects.
On Saturday, Ruto will commission Sh500 million dam project in Pemba in Kwale and then head to Mombasa on Sunday. In Mombasa, he will unveil Sh300 million sewerage works.
The project, which was funded by the African Development Bank in Changamwe, is expected to transform the county in terms of cleanliness.
He will end his tour on Monday where he is expected to be in Taita Taveta.
The tour comes at a time when calls for referundum have intensfied.