Europe's crème de la crème club football returns on Tuesday night after two months' break with the round of 16 knock-out stage matches.
Here are our well researched and analysed tips to stake on.
At this stage, there is no taking hostages.
PSG travel to meet United at Old Trafford without sensational star Neymar Junior who is doubtful for Old Trafford trip due to injury on his right metatarsal and is expected to be out for 10 weeks.
While Edison Cavani is also doubtful for the match after picking a knock against Bordeaux on Sunday and Parisian will bank on Italian shot-stopper Gianluigi Buffon to deliver them from on song Martial and Pogba.
Whether it's Thomas Tuchel's mind game on the duos injury update, it remains to be seen as United under the tutelage of caretaker manager Ole Gunnar Solskjaer are on the good run with 10 wins out of 11 matches since Norwegian took over from Mourinho.
Both teams are on a good run and the odds stand at 50/50 on the Red Devils against Parisians.
The other match will see Roma host Sergio Conceicao's Porto at Stadio Olimpico in the UEFA champions league last 16 leg. The Dragons will hope to get an away goal while Roma will bank on Edin Dzeko.
On Wednesday the action resumes as holders Real Madrid visit Johan Cruijff Arena to play Ajax.
Santiago Solari side is favoured to carry the day despite both teams having a good run in the competition.
While Mauricio Pochettino’s Spurs is tipped to overcome Borrusia Dortmund who also are on top form.
i. UEFA champions league:
Man Utd vs PSG (1X)
Roma vs FC Porto (X2)
Ajax vs Real Madrid (2)
Tottenham vs Borrusia Dortmund (1X)
ii. Europa League Final Stage
Fenerbahce vs Zenit St. Petersburg (X2)
iii. Copa Libertadores Q
Atletico MG vs Danubio (1X)
iv. Copa Sudamericana
River Plate vs Santos FC (1X)
v. CAF champions league
ASEC Mimosas vs Mamelodi Sundowns (X2)
Wydad Casablanca vs Lobi Star (1X)
Esperance vs Orlando Pirates (1X)
Horoya AC vs FC Platinum (1X)
CCS Constantine vs Ismaily SC (1X)
Club Africain vs TP Mazembe (X2)
Simba SC vs Al Ahly (2)
JS Saoura vs AS Vita Club (1X)