Five people died on the spot after the matatu they were traveling in hit a truck at Chebiwor in Londiani along the Nakuru-Kericho highway.
Seven others have been seriously injured following the Sunday morning road crash.
Among those who died were three women and two men.
The bodies of the deceased were taken to Molo Sub County Hospital mortuary in Nakuru County.
The injured passengers were rushed to Londiani Sub County Hospital and later referred to the Kericho County Hospital.
Confirming the incident, Londiani OCPD Joseph Odipo said the Transline Shuttle matatu was heading to Nairobi from Busia when the accident happened.
"Five passengers lost their lives on the spot while seven were seriously injured. The drivers of the two vehicles were among those who sustained serious injuries,” said Odipo, as reported by The Nation.
The OCPD said the driver of the matatu was speeding and trying to overtake the truck that was ferrying iron sheets to Kericho.
"Many accidents have occurred in this area. It is a known black spot where speeding, overtaking and careless driving are the major causes of accidents," he said.
Wreckages of the two vehicles were towed to Londiani Police Station.