Chelsea lost 3-0 to As Roma in the midweek game to fight for the top spot in group C in Champions League while Man Utd won 2-0 to cement their top spot in group A.
Now the action returns to the Premier League as they look to get their title defence back on track.
Their 1-0 win at Bournemouth last weekend leaves them 4th in the table, already nine points behind the unstoppable Manchester City.
Antonio Conte built his title-winning side around their home form last season, but so far Chelsea have failed to deliver at Stamford Bridge.
They have won just two of their five Premier League games there, failing to score twice in the process and losing to Manchester City and Burnley.
Fortunately for them, their defence is unlikely to come under a huge amount of pressure, given Jose Mourinho’s approach to these big games. Mourinho showed his hand when he took Manchester United to Anfield, playing extremely defensively and taking a point back home after a goalless draw.
It’s not just away to the big teams that Manchester United have struggled to score against recently though.
They have only scored seven goals in their last six competitive games, which is a far cry from the side that scored 22 times in the seven games preceding this run.
Away from home in the Premier League, they have dropped points on three occasions this season and last time out lost to Huddersfield.
Complacency won’t be an issue against Chelsea, but even with their fragile defence it won’t be easy for The Red Devils to break them down when they’re in this form.
All this has the makings of a low scoring affair between two teams who are likely to set up not to lose. Five of the last six meetings between the teams has seen fewer than three goals, so we’re backing Under 2.5 Goals for our main predictions.
In the end, this has stalemate written all over it with both teams desperate not to lose, so we’re also going for a draw alongside 1-1 correct score predictions.
Chelsea has won three, drawn two, and lost one of their last six meetings with Manchester United, with there being fewer than three goals in five of these games.
N'Golo Kante is unlikely to be fit to play on Sunday but shouldn't be out for too much longer, whilst Victor Moses remains sidelined too.
Long-term injury problems Zlatan Ibrahimovic, Marcos Rojo, and Paul Pogba all miss out again, along with Michael Carrick.
Marouane Fellaini is a major doubt but is a possibility to return, whilst Jesse Lingard is expected to shake off a minor back injury.