Deputy President William Ruto could find himself in a precarious position should the country go for a referendum.
Already, Ruto, who now seems to be isolated by the top leadership, has warned against any changes that could introduce parliamentary system of government.
"The decision should be made by people. Those who want us to have Prime Minister appointed by parliamentary are wrong. We are not ready for such moves," he said at a function.
Conspicuously, President Uhuru Kenyatta has remained mum over the matter, an indication that he could have agreed with Raila to amend the constitution to change leadership structure.
With KANU's Gideon Moi backing the referendum push, ANC and Ford Kenya have joined Raila's bandwagon, a move that could even complicate matters for Ruto.
"We want to see the country moving to a parliamentary system of government that will be all inclusive in terms of representation," said Wetangula, who had earlier backed Ruto's position.
On his part. Musalia Mudavadi said: "If you ask whether I support the referendum, the answer is yes. We want to see changes as envisaged in the Bomas Draft."
Although he has not come out open about the proposed changes by Raila, Wiper leader Kalonzo Musyoka has also indicated that he would support the plebiscite.
In Jubilee,a number of leaders among them Moiben MP Silas Tiren and Nyeri Town's Ngunjiri Wambugu, are supporting the changes, a move that could leave Ruto walking on his own.